Anti-CD47 Antagonist Antibody

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Applications: Useful as an antagonist to block CD47 signaling and binding to SIRP-α or SIRP-γ in biochemical assays.

Background: Cluster of Differentiation 47, or CD47, plays an essential role in cell growth, death, migration, and adhesion. CD47 binding to SIRP-α mediates phagocytosis by sending a "do not eat me" signal to phagocytes. CD47 proteins are often over expressed by tumor cells as a means for them to escape phagocytosis. As a result, cancerous tumor cells have the ability to proliferate and evade the immune system.

Description: Anti-CD47 recombinant human antagonist antibody recognizing the SIRP-α or SIRP-γ binding region of human CD47. This antibody has not been tested for cross-reactivity with any other species.

Format: Aqueous buffer solution

Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.

Purification: Protein A affinity chromato-graphy from HEK293 supernatants.

Storage Stability: Stable for at least 12 months at -80°C. Protect from light. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.

Uniprot: Q08722

Biosafety Level: Not applicable (BSL-1)

References: 1.Vernon-Wilson, E.F. et al., Eur. J. Immunol. 2000; 30(8): 2130-2137. 2.Majeti, R. et al., Cell. 2009; 138(2): 286- 299.

• Artikelnummer: BPS79065-1
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79065-1
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Klonalität: Monoclonal
• Isotyp: IgG1