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Application: Useful for studying CDH17 expression on the cell surface by flow cytometry.
Background: CDH17 (cadherin 17), also known as LI (liver-intestine)-cadherin is a unique member of the cadherin superfamily of proteins, as it has seven instead of the five typical cadherin domains. It is a calcium-dependent membrane-associated glycoprotein normally expressed on epithelial cells of the small intestine and colon, where it regulates intercellular adhesion. Upregulation of this protein is found in gastric cancer, colorectal and pancreatic cancer, amongst others. CDH17 has become a therapeutic target of interest, with studies using monoclonal antibodies, ADC (antibody drug conjugates) and CAR (chimeric antigen receptor)-T cells resulting in promising outcomes.
Clone Number: Monoclonal
Cross Reactivity: This antibody recognizes human CDH17. It has not been tested with other species.
Description: The FluoSite™ Anti-CDH17 (cadherin 17) Antibody is a purified monospecific antibody, which is labeled with Allophycocyanin (APC). This antibody has been tested by flow cytometry for binding to human CDH17 on CDH17 (Cadherin 17) HEK293 Cell Line. FluoSite™ is a tag-based method for site-specific conjugation of antibodies with fluorophores, ensuring the labeling site is far from the antigen-binding domain to preserve antibody functionality. This precise, consistent labeling ensures the homogeneity of the labeled antibody preparation, making it ideal for flow cytometry and other high-sensitivity applications.
Format: Aqueous buffer solution.
Formulation: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 0.09% Sodium Azide, 0.2% BSA, and up to 20% glycerol. May contain a protein stabilizer.
Purification: Protein A affinity chromatography from HEK293 supernatants.
Purity: ≥90%
Storage Stability: At least 6 months at 4°C. Protect from prolonged exposure to light. DO NOT FREEZE. The antibody solution should be stored undiluted between 2°C and 8°C.
Target: CDH17
Uniprot: Q12864
Warnings: Do not freeze. Protect from light.
Biosafety Level: Not applicable (BSL-1)
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