Target Synonym: TKR;ERBB;erb-b2 receptor tyrosine kinase;Receptor tyrosine-protein kinase erbB;Tyrosine kinase-type cell surface receptor HER;HER2/ErbB;HER;MLN;ERBB2;CD340;HER-2;HER-2/neu;HER2;MLN 19;NEU;NGL;TKR1;erb-b2 receptor tyrosine kinase 2;HER2/ErbB2;MLN19;Metastatic lymph node gene 19 protein;p185;Proto-oncogene Neu;Receptor tyrosine-protein kinase erbB-2;Tyrosine kinase-type cell surface receptor HER2;Neu;erb-B2;CD340;erb-b2 receptor tyrosine kinase 2;HER2;HER-2;HER-2/neu;MLN 19;MLN19;NGL;TKR1;C erb B2/neu protein;CD340 antigen;Cerb B2/neu protein;CerbB2;ENV;ENVW;Erb b2 receptor tyrosine kinase 2;ERVWE1;HER 2;HER 2/NEU;Herstatin;HERV7Q;HERV-7q;HERVW;HERVWENV;HERV-W-ENV;Human epidermal growth factor receptor 2;NEU proto oncogene;neuro/glioblastoma derived oncogene homolog;neuro/glioblastoma derived oncogene homolog (avian);Neuroblastoma/glioblastoma derived oncogene homolog;p185erbB2;Proto-oncogene c-ErbB-2;Tyrosine kinase type cell surface receptor HER2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog);V erb b2 avian erythroblastic leukemia viral oncoprotein 2;V erb b2 erythroblastic leukemia viral oncogene homolog 2;Verb b2 erythroblastic leukemia viral oncogene homolog 2
Background: ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.
Immunogen: Recombinant Human HER2/ErbB2/CD340 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:100-1:500;ICC/IF 1:20-1:100;FCM 1:25-1:100;
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