Target Synonym: BCL2L;BBC;BAD;BBC2;BCL2L8;BBC6;AI325008;BBC 2;Bcl 2 Antagonist of Cell Death;Bcl 2 Binding Component 6;BCL X/BCL 2 Binding Protein;BCL X Binding Protein;Bcl XL/Bcl 2 Associated Death Promoter;Bcl2 antagonist of cell death;BCL2 antagonist of cell death protein;BCL2 associated agonist of cell death;Bcl2 Associated Death Promoter;BCL2 binding component 6;BCL2 binding protein;Bcl2 Like 8 Protein;Bcl-2-binding component 6;Bcl2-L-8;Bcl-2-like protein 8;Bcl-XL/Bcl-2-associated death promoter;Proapoptotic BH3 Only Protein
Background: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-1, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Immunogen: A synthetic peptide corresponding to the residues around Ser99 of Human Phospho-Bad
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:1000-1:20000;
Calculated MW: 18 kDa
Observed MW: 18 kDa
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