Target Synonym: NR3A;nuclear receptor subfamily;Nuclear Receptor Subfamily 3 Group A Member;member;ESR1;ER;ESR;ESRA;ESTRR;Era;NR3A1;ER alpha;ER-Alpha;Estradiol Receptor;Estrogen Receptor;Estrogen Receptor α;group A;member 1;nuclear receptor subfamily 3;Nuclear Receptor Subfamily 3 Group A Member 1;7*/654 isoform;7*/819 2 isoform;7*/822 isoform;8*/901 isoform;8*/941 isoform;DKFZp686N23123;Estrogen nuclear receptor alpha;Estrogen receptor 1;Estrogen receptor alpha;Estrogen receptor alpha 3*;Estrogen receptor alpha delta 3*;Estrogen receptor alpha delta 4 +49 isoform;Estrogen receptor alpha E1 E2 1 2;Estrogen receptor alpha E1 N2 E2 1 2
Background: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Immunogen: A synthetic peptide corresponding to the center region of the Human ER alpha/ESR1
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000
Calculated MW: 66 kDa
Observed MW: 79 kDa
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