Target Synonym: FCGRT;FCRN;alpha-chain;alpha;heavy chain;intestinal;receptor transporter;Alpha chain;Fc fragment of IgG;FCGRN_HUMAN;FcRn alpha chain;IgG Fc fragment receptor transporter alpha chain;IgG Gc receptor;IgG receptor FcRn large subunit p51;IgG receptor FcRn large subunit p51 precursor;Immunoglobulin receptor;Neonatal Fc receptor;IMD;Beta-2-microglobulin form pI;CDABP;B2M;IMD43;B2MG;Beta 2 microglobin;Beta 2 microglobulin;Beta 2 microglobulin precursor;Beta chain of mhc class 1 proteins;Beta chain of MHC class I molecules;Beta-2-Microglobulin;Beta-2-microglobulin form pI 5.3;β2M;β2-Microglobulin;CDABP0092;HDCMA22P
Background: FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Immunogen: Recombinant Human FCGRT & B2M Heterodimer protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:100-1:500
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