Target Synonym: NFKB;Transcription factor p;Nuclear factor of kappa light polypeptide gene enhancer in B-cells;NF-kB p;NFKB3;p65;NF-kB p65;RELA;CMCU;Transcription factor p65;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;NFKB3;p65;transcription factor p65;Avian reticuloendotheliosis viral (v rel) oncogene homolog A;MGC131774;NF kappa B p65delta3;Nuclear Factor NF Kappa B p65 Subunit;Nuclear factor of kappa light polypeptide gene enhancer in B cells 3;OTTHUMP00000233473;OTTHUMP00000233474;OTTHUMP00000233475;OTTHUMP00000233476;OTTHUMP00000233900;p65 NF kappaB;p65 NFkB;TF65;V rel avian reticuloendotheliosis viral oncogene homolog A;v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65));V rel reticuloendotheliosis viral oncogene homolog A;v rel reticuloendotheliosis viral oncogene homolog A (avian)
Background: 65 is a subunit of the nuclear factor kappa B. The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear accumulation of NFkB by the induced phosphorylation and subsequent degradation of IkB.
Immunogen: A synthetic phosphopeptide corresponding to residues around Ser536 of the Human NF-κB p65
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:2000-1:20000
Calculated MW: 65 kDa
Observed MW: 70 kDa
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