Target Synonym: BCC;LFS;TRP;BMFS;Antigen NY-CO;Tumor protein;Phosphoprotein p;Tumor suppressor p;Mutant tumor protein;Cellular tumor antigen p;Transformation related protein;BCC7;LFS1;P53;TRP53;TP53;BMFS5;Antigen NY-CO-13;Cellular tumor antigen p53;FLJ92943;Mutant tumor protein 53;p53 tumor suppressor;Phosphoprotein p53;Transformation related protein 53;Tumor protein 53;Tumor protein p53;Tumor suppressor p53;BCC7;LFS1;P53;TRP53;tumor protein p53;Antigen NY-CO-13;BCC7;Cellular tumor antigen p53;FLJ92943;LFS1;Mutant tumor protein 53;p53;p53 tumor suppressor;P53;Phosphoprotein p53;Tp53;Transformation related protein 53;TRP53;Tumor protein 53;Tumor protein p53;Tumor suppressor p53
Background: The p53 tumor suppressor protein is a multi-functional transcription factor that regulates cellular decisions regarding proliferation, cell cycle checkpoints, and apoptosis. The importance of p53 is underscored by its mutation in over 50% of human cancers. Mice that lack one or both copies of p53 also showed an increased incidence of tumors, which makes the p53 deficient mouse a model system for studying cancer generation and progression.
Immunogen: A synthetic phosphopeptide corresponding to residues around Ser15 of the Human Phospho-p53
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:1000-1:5000
Calculated MW: 43 kDa
Observed MW: 43 kDa
Deutsch
English
