Target Synonym: EIF2AK;Pek;Perk;Eif2ak3
Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Buffer: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen: A synthetic peptide corresponding to residues around (Thr980) of Mouse Phospho-PERK
Dilution: WB 1:2000-1:10000;
Calculated MW: 125 kDa
Observed MW: 125 kDa