Target Synonym: FTDP;PPP1R;DDPAC;FTDP-17;MAPTL;MSTD;MTBT1;MTBT2;PPND;PPP1R103;TAU;MAPT;Microtubule-Associated Protein Tau;Neurofibrillary Tangle Protein;Paired Helical Filament-Tau;PHF-Tau;pMAPT/pTAU;TAU and MAPT;N/A;AI413597;AW045860;FLJ31424;FTDP 17;G protein beta1/gamma2 subunit interacting factor 1;included;MGC134287;MGC138549;MGC156663;Microtubule associated protein tau;Microtubule associated protein tau isoform 4;Mtapt;Paired helical filament tau;PHF tau;Protein phosphatase 1;pTau;regulatory subunit 103;RNPTAU;Tauopathy and respiratory failure
Background: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Immunogen: A synthetic phosphopeptide corresponding to residues around
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:2000-1:10000
Calculated MW: 78 kDa
Observed MW: 50-80 kDa
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