Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine
Purity: ≥98%
Formula Markup: C16H16F3N3
Formula Weight: 307.3
CAS Number: 1430208-73-3
Notes: An inhibitor of Rac1 (IC50 = 4 µM); reduces the secretion of CXCL5, CXCL10, HGF, CCL2, and MMP-2 from patient-derived AML cells at 20 µM; inhibits the proliferation and migration of, and induces apoptosis in, LN-229 glioblastoma cells at 10 hours, but not 23 hours, post-synchronization at 20 µM; decreases the number of lung nodules and macronodules, as well as total lung weight, in a F3II murine breast cancer model of lung tumor formation at 3 mg/kg per day; inhibits the asexual replication of the P. falciparum strains D10 and W2 (IC50s = 3.21 and 6.89 µM, respectively) and sexual replication in P. falciparum 3D7 immature and mature gametocytes (IC50s = 78.13 and 56.64 µM, respectively)
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