3-Hydroxy Midostaurin-d5

Product Description: 3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

Applications: Cancer-Kinase/protease

Formula: C35H25D5N4O5

References: [1]Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.

Molecular Weight: 591.67

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: FLT3;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-108263S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-108263S-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK