Product Description: Avibactam sodium salt-13C5 (NXL-104-13C5) is 13C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1][2].
Formula: C2 13C5H10N3NaO6S
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304./[3]Ehmann DE, et al.
Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8./[4]Livermore DM, et al.
Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104).
J Antimicrob Chemother. 2012 Jun;67(6):1354-8./[5]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.
Molecular Weight: 292.19
Research Area: Infection
Target: Antibiotic;Bacterial;Beta-lactamase;Isotope-Labeled Compounds
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