Product Description: BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium[1].
Applications: COVID-19-immunoregulation
Formula: C22H18D3FN6O3
References: [1]Chunjian Liu, et al. Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2. J Med Chem. 2021 Jan 14;64(1):677-694.
CAS Number: 1771691-34-9
Molecular Weight: 439.46
Compound Purity: 99.92
Research Area: Inflammation/Immunology
Solubility: DMSO : 250 mg/mL (ultrasonic)
Target: Cytochrome P450;JAK
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