Product Description: Cetirizine-d4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C21H21D4ClN2O3
References: [1]Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993./[2]Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5./[3]Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.
CAS Number: 1219803-84-5
Molecular Weight: 392.91
Compound Purity: 98.0
Research Area: Inflammation/Immunology
Solubility: 10 mM in H2O/DMSO : 250mg/mL (ultrasonic)
Target: Histamine Receptor
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