Product Description: Citrinin-13C13 (NSC 186-13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity[1][2][3][4][5][6][7].
Applications: Cancer-programmed cell death
Formula: 13C13H14O5
References: [1]de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141./[2]Čulig B, et al. PRESENCE OF CITRININ IN GRAINS AND ITS POSSIBLE HEALTH EFFECTS. Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):22-30/[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220./[4]Islam MR, et al. Immune modulatory effects of the foodborne contaminant citrinin in mice. Food Chem Toxicol. 2012 Oct;50(10):3537-47. /[5]de Oliveira Filho JWG, et al. Citrinin against breast cancer: A cytogenotoxicological study. Phytother Res. 2021 Jan;35(1):504-516./[6]Wu Y, et al. Citrinin exposure affects oocyte maturation and embryo development by inducing oxidative stress-mediated apoptosis. Oncotarget. 2017 May 23;8(21):34525-34533./[7]Nakajima Y, et al. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J Toxicol Sci. 2016 Apr;41(2):311-9.
Molecular Weight: 263.15
Research Area: Cancer; Infection; Neurological Disease
Solubility: 10 mM in DMSO
Target: Apoptosis;Autophagy;Bacterial;Isotope-Labeled Compounds
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