Difelikefalin-d5

Product Description: Difelikefalin-d5 (CR-845-d5) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C36H48D5N7O6

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Steven Fishbane, et al. Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients. Kidney Int Rep. 2020 Jan 28;5(5):600-610./[3]Steven Fishbane, et al. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients With Pruritus. N Engl J Med. 2020 Jan 16;382(3):222-232.

Molecular Weight: 684.88

Research Area: Neurological Disease

Target: Isotope-Labeled Compounds;Opioid Receptor

• Artikelnummer: MEXHY-17609S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-17609S-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK