Product Description: Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4[1].
Applications: Neuroscience-Neuromodulation
Formula: C31H38D6N2O5S
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120(7):636-44./[3]Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna). 2019 Feb;126(2):115-122.
CAS Number: 1132693-87-8
Molecular Weight: 562.79
Research Area: Cardiovascular Disease
Target: Adrenergic Receptor;Autophagy;Calcium Channel;Cytochrome P450;Isotope-Labeled Compounds;mAChR;Sodium Channel
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