Product Description: Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
Applications: Cancer-programmed cell death
Formula: C24H17D4F2NO3
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63./[3]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.
CAS Number: 1093659-89-2
Molecular Weight: 413.45
Compound Purity: 99.26
Research Area: Cardiovascular Disease; Cancer
Solubility: 10 mM in DMSO/DMSO : 200mg/mL (ultrasonic)/H2O : 0.1mg/mL (ultrasonic;warming;heat to 60°C)
Target: Autophagy;Keap1-Nrf2
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