Product Description: Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively[1].
Applications: Cancer-Kinase/protease
Formula: C26H28D3Cl2N7O3
References: [1]Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T
Molecular Weight: 563.49
Compound Purity: 98.90
Research Area: Cancer
Solubility: DMSO : 12 mg/mL (ultrasonic;warming)
Target: FGFR