Product Description: Isotretinoin-d5 is the deuterium labeled Isotretinoin. Isotretinoin is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity[1][2][3].
Applications: Cancer-programmed cell death
Formula: C20H23D5O2
References: [1]Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May;1(3):162-9./[2]Dahl AR, et al. Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug;6(8):3015-24/[3]Bergoli RD, et al. Isotretinoin effect on alveolar repair after exodontia--a study in rats. Oral Maxillofac Surg. 2011 Jun;15(2):85-92./[4]Ramírez-Flores PN, et al. Isotretinoin and Thalidomide Down-Regulate c-MYC Gene Expression and Modify Proteins Associated with Cancer in Hepatic Cells. Molecules. 2021 Sep 22;26(19):5742./[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Molecular Weight: 305.47
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Autophagy;Endogenous Metabolite;Isotope-Labeled Compounds;RAR/RXR
Deutsch
English
