Notes: JWH 081 (Item No. 10579) is a cannabimimetic indole related to JWH 015 (Item No. 10009018) and JWH 018 (Item No. 10900) that shows preference for the central cannabinoid (CB1) receptor (Ki = 1.2 nM) over the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM).{16797,18232} JWH 081 N-(4-hydroxypentyl) metabolite is an expected product of the phase I metabolism of JWH 081, based on studies on the metabolism of the related synthetic cannabinoids JWH 018 and JWH 073 (Item No. 10904).{19353,20170} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic purposes.