Lacidipine-13C8, CAS 1261432-01-2

Lacidipine-13C8, CAS 1261432-01-2
Artikelnummer
MEXHY-B0347S1-1
Verpackungseinheit
1 mg
Hersteller
MedChemExpress

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Product Description: Lacidipine-13C8 is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

Applications: Neuroscience-Neurodegeneration

Formula: C18 13C8H33NO6

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Zhang A, et al. Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem. 2013;32(4):1040-9. /[3]Cristofori P, et al. The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse. J Hypertens. 2000 Oct;18(10):1429-36.

CAS Number: 1261432-01-2

Molecular Weight: 463.48

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Apoptosis;Calcium Channel;Caspase;Reactive Oxygen Species
Mehr Informationen
Artikelnummer MEXHY-B0347S1-1
Hersteller MedChemExpress
Hersteller Artikelnummer HY-B0347S1-1
Verpackungseinheit 1 mg
Mengeneinheit STK
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