Lifitegrast-d4

Product Description: Lifitegrast-d4 (SAR 1118-d4) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease[1][2].

Formula: C29H20D4Cl2N2O7S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 619.51

Research Area: Inflammation/Immunology

Target: Isotope-Labeled Compounds

• Artikelnummer: MEXHY-19344S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19344S-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK