Product Description: Lofexidine-d4 is deuterium labeled Lofexidine (hydrochloride). Lofexidine (hydrochloride) is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2][3].
Formula: C11H8D4Cl2N2O
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9(11):1371-7./[3]Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44(2):343-51.
CAS Number: 78302-26-8
Molecular Weight: 263.16
Research Area: Neurological Disease;Endocrinology
Target: Adrenergic Receptor;Isotope-Labeled Compounds
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