MRTX-1257-d6, CAS 2639608-44-7

Product Description: MRTX-1257-d6 is the deuterium labeled MRTX-1257 (HY-114436). MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1][2].

Applications: Cancer-programmed cell death

Formula: C33H33D6N7O2

References: [1]Matthew et al. Structure-Based Drug Discovery of MRTX1257, a Selective, Covalent KRAS G12C Inhibitor with Oral Activity in Animal Models of Cancer./[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220.

CAS Number: 2639608-44-7

Molecular Weight: 571.75

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Isotope-Labeled Compounds

• Artikelnummer: MEXHY-114436S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-114436S-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK