Product Description: N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2][3][4].
Applications: Cancer-programmed cell death
Formula: C5D9NO
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Malek DE, et al. Repeated dose toxicity study (28 days) in rats and mice with N-methylpyrrolidone (NMP). Drug Chem Toxicol. 1997 Feb-May;20(1-2):63-77. /[3]Malley LA, et al. 90-day subchronic toxicity study in rats and mice fed N-methylpyrrolidone (NMP) including neurotoxicity evaluation in rats. Drug Chem Toxicol. 1999 Aug;22(3):455-80. /[4]Jing Wang, et al. Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization. Bioresour Technol. 2019 Dec;294:122185./[5]Claudia Julieta Solís-González, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2017 Dec 15;84(1):e02136-17.
CAS Number: 185964-60-7
Molecular Weight: 108.19
Research Area: Cancer
Target: Biochemical Assay Reagents;Isotope-Labeled Compounds
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