Roflumilast-d4 N-Oxide, CAS 1794760-31-8

Roflumilast-d4 N-Oxide, CAS 1794760-31-8
Artikelnummer
MEXHY-15455S1-100UG
Verpackungseinheit
100 μg
Hersteller
MedChemExpress

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Product Description: Roflumilast-d4 N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells[1][2].

Formula: C17H10D4Cl2F2N2O4

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Ding H, et al. Treatment of obesity-associated overactive bladder by the phosphodiesterase type-4 inhibitor roflumilast. Int Urol Nephrol. 2017 Jul 29./[3]Hatzelmann A, et al. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther. 2001 Apr;297(1):267-79./[4]Hatzelmann A, et al. The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2010 Aug;23(4):235-56./[5]Rabe KF. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol. 2011 May;163(1):53-67./[6]Richmond BW, et al. Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nat Commun. 2016 Apr 5;7:11240.

CAS Number: 1794760-31-8

Molecular Weight: 423.23

Compound Purity: 98.13

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO/H2O : 0.1mg/mL (ultrasonic)

Target: Phosphodiesterase (PDE);RSV
Mehr Informationen
Artikelnummer MEXHY-15455S1-100UG
Hersteller MedChemExpress
Hersteller Artikelnummer HY-15455S1-100UG
Verpackungseinheit 100 μg
Mengeneinheit STK
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