AZD 3458, CAS 2132961-46-5

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-(methylsulfonyl)-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]-acetamide

Purity: ≥98%

Formula Markup: C20H23N3O4S2

Formula Weight: 433.54644

CAS Number: 2132961-46-5

Notes: A PI3Kγ inhibitor (IC50 = 0.79 nM); selective for PI3Kγ over PI3Kα, PI3Kβ, and PI3Kδ (IC50s = 7.94, >31.62, and 0.316 µM, respectively), PI3KC2α, PI3KC2γ, and PI3KC3 (IC50s = >10, 3.16, and 7.94 µM, respectively), and a panel of 395 kinases at 1 µM but does inhibit PI3KC2β (IC50 = 31.62 nM); reduces LPS-induced increases in BALF neutrophils in a rat model of acute lung inflammation at 0.1, 0.5, and 2.5 mg/kg

• Artikelnummer: CAY42104-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42104-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK