BI-2536, CAS 755038-02-9

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CAS Number: 755038-02-9

Description: BI-2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. BI-2536 has an IC₅₀ of 0.83 and 25 nM with PLK1 and BRD4 inhibitor, respectively. BI-2536 also blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC₅₀ of 3.5 nM and 9.0 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-ß) gene transcription. It also shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.

Format: Solid

Purity: 0,95

Storage Stability: At least 6 months at -20°C.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS82062-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 82062-2
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK