EGFR-IN-7, CAS 2267329-76-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5-bromo-N4-[5-(dimethylphosphinyl)-6-quinoxalinyl]-N2-[2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine

Purity: ≥95%

Formula Markup: C32H41BrN9O2P

Formula Weight: 694.605161

CAS Number: 2267329-76-8

Notes: An inhibitor of wild-type and mutant EGFR (IC50s = 1.07, 0.46, 0.13, 0.26, and 0.19 nM for wild-type EGFR, EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M, respectively); inhibits the proliferation of wild-type EGFR-expressing A431, EGFRd746-750/T790M/C797S-expressing Ba/F3, EGFRd746-750/T790M/C797S-expressing H1975, and EGFRd746-750-expressing PC-9 cells (IC50s = 147, 26.8, 163, and 45 nM, respectively); reduces tumor growth in triple mutant EGFR mouse xenograft models

• Artikelnummer: CAY42214-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42214-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK