BSJ-4-116, CAS 2519823-34-6

Formulation: A solid

Formal Name: N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetamide

Purity: ≥95%

Formula Markup: C40H49ClN8O8S

Formula Weight: 837,4

Shelf life (days): 1460

CAS Number: 2519823-34-6

Notes: BSJ-4-116 is a proteolysis-targeting chimera (PROTAC) composed of a modified form of the multi-kinase degrader TL12-186 linked to the cereblon ligand and PROTAC synthetic intermediate E3 ligase ligand 2 (Item No. 36664).{67542} It induces time- and concentration-dependent degradation of cyclin-dependent kinase 12 (Cdk12) in Jurkat T cells. BSJ-4-116 (50 nM) decreases expressions of various genes associated with DNA double-strand break repair in Jurkat cells. It inhibits the growth of MOLT-4 leukemia cells in a cereblon-dependent manner.

• Artikelnummer: CAY39564-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39564-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK