Ferritin PROTAC DeFer-2

Formulation: A solid

Formal Name: (2S,4R)-1-((S)-3,3-dimethyl-2-(4-oleamidobutanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Formula Markup: C44H69N5O5S

Formula Weight: 780,1

Shelf life (days): 1095

Notes: Ferritin PROTAC DeFer-2 is a proteolysis-targeting chimera (PROTAC) containing oleic acid (Item Nos. 90260 / 24659), which binds to ferritin dimers, conjugated to von Hippel-Lindau ligand (VHL ligand 1; Item No. 21591), which binds to VHL E3 ligase, via an alkyl linker.{68446} It induces ferritin degradation in B16/F10 murine melanoma cells when used at a concentration of 0.5 µM, an effect not induced by a negative control with an inverted VHL ligand 1 stereocenter, indicating that the E3 ligase activity of VHL ligand 1 is required for this effect. Ferritin PROTAC DeFer-2 (5 µM) increases intracellular levels of free iron and induces pyroptosis in B16/F10 cells. Ferritin PROTAC De-Fer-2 (10 mg/kg) encapsulated in albumin nanoparticles reduces tumor growth and increases survival in a B16/F10 murine melanoma model.

• Artikelnummer: CAY38931-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38931-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK