JQAD1, CAS 2417097-18-6

Formulation: A solid

Formal Name: 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)dodecanamide

Purity: ≥98%

Formula Markup: C48H52F4N6O9

Formula Weight: 933

Shelf life (days): 1460

CAS Number: 2417097-18-6

Notes: JQAD1 is a proteolysis-targeting chimera (PROTAC) composed of the p300 and CREB-binding protein (CBP) inhibitor A-485 (Item No. 24119) conjugated to a cereblon (CRBN) ligand.{69514} It selectively induces the degradation of p300 over CBP in Kelly MYCN-amplified neuroblastoma cells when used at a concentration of 10 µM for 24 hours. JQAD1 (0.5 µM) decreases histone 3 lysine 27 (H3K27) acetylation and induces apoptosis in Kelly cells. In vivo, JQAD1 (40 mg/kg) decreases tumor volume, increases survival, and reduces tumoral p300 but not CBP levels in a Kelly neuroblastoma mouse xenograft model.

• Artikelnummer: CAY39566-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39566-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK