Thioredoxin Glutathione Reductase (Schistosoma mansoni, recombinant)

Formulation: TE buffer with 50% glycerol

Purity: ≥95% estimated by SDS-PAGE

Shelf life (days): 365

Notes: Thioredoxin glutathione reductase (TGR) is a selenocysteine-containing oxidoreductase flavoenzyme that protects Schistosoma, the genus of blood flukes that causes schistosomiasis, and other helminth parasites from host-induced oxidative damage.{72051,72052} It is a homodimer that contains an N-terminal glutathione reductase domain, an FAD- and NADPH- binding site, and a thioredoxin domain near the C-terminus, and it can reduce both DTNB and oxidized glutathione (GSSH).{72052} TGR catalyzes NADPH- and FAD-dependent reduction of oxidized thioredoxin (Trx), glutathione (GSH), and glutaredoxin (Grx), which mitigate the effects of reactive oxygen and nitrogen species released by host neutrophils and macrophages that can damage intracellular proteins and lipids.{72053} Cayman's TGR (Schistosoma mansoni, recombinant) protein can be used for enzyme activity assays.

• Artikelnummer: CAY39632-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39632-250
• Green Labware: Nein
• Verpackungseinheit: 250 µg
• Mengeneinheit: STK
• Methode: Enzyme Activity