Notes: VH 032 amide C7 acid is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal carboxylic acid conjugated via a heptyl linker to VHL ligand 1 (Item No. 21591), which binds to von Hippel-Lindau (VHL) E3 ligase.{51899} It has been used in the synthesis of PROTACs targeting anaplastic lymphoma kinase (ALK) in cancer cells.