Shelf life (days): 1460.0
Formulation: A solid
Formal Name: [(3R)-3-amino-1-piperidinyl][2-[1-[(4-fluorophenyl)methyl]-1H-indol-2-yl]-3-methylimidazo[1,2-a]pyridin-7-yl]-methanone
Purity: ≥98%
Formula Markup: C29H28FN5O
Formula Weight: 481.564123
CAS Number: 2308504-22-3
Notes: A PAD4 inhibitor (IC50 = 0.122 µM); selective for PAD4 over PAD1, PAD2, PAD3, and PAD6 at 30 µM; inhibits calcium-induced increases in H3Cit levels and NET formation in isolated human neutrophils at 10 µM; decreases serum IL-6 and plasma H3Cit levels and ankle joint inflammation and erosion levels in a mouse model of GM-CSF- and collagen-induced arthritis at 20 mg/kg twice per day; reduces tumor size and tumor-associated neutrophil levels and increases tumor Cd8+ T cell and Cd4+ T cell levels but also decreases splenic macrophage, Cd4+ T cell, and Treg levels in an LL/2 murine lung cancer model
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