Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methyl-piperazine, 2Z-butenedioate
Purity: ≥98%
Formula Markup: C13H15ClN4O / C4H4O4
Formula Weight: 394.8
CAS Number: 869497-75-6
Notes: A histamine H4 receptor antagonist (Ki = 79.42 nM); selective for the histamine H4 receptor over the histamine H3 receptor (Ki = 3,981 nM); inhibits eosinophil and mast cell chemotaxis (IC50s = 530 and 138 nM, respectively); decreases colonic injury in a rat model of TNBS-induced colitis at 30 and 100 mg/kg and reduces colonic mucosal and submucosal thickness at 100 mg/kg in the same model; reduces the percentage of Th1, Th9, Th17, and regulatory T cells in the spleen, the expression of a variety of cytokines, including Ifng, Il9, and Tgfb1, in the brain, and the development of EAE in mice at 6 mg/kg
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