Dianhydrogalactitol, CAS 23261-20-3

Formulation: A solid

Formal Name: 1,2:5,6-dianhydro-galactitol

Purity: ≥95%

Formula Markup: C6H10O4

Formula Weight: 146,1

Shelf life (days): 1460

CAS Number: 23261-20-3

Notes: Dianhydrogalactitol is a hexitol epoxide DNA alkylating agent that has been found in P. caesiopruinosa.{67347,67348} It induces N7-alkylation of guanine and interstrand DNA cross-links in vitro.{67347} Dianhydrogalactitol (0.5-8 µM) halts the cell cycle at the G2/M phase in U-251MG and T98G glioblastoma cells.{67349} It decreases the migration and invasion of U251 glioblastoma cells and tube formation of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 12.5 µg/ml.{67350} Dianhydrogalactitol (2.5 mg/kg) increases survival in a U-251MG mouse xenograft model when administered in combination with the alkylating agent prodrug temozolomide (Item No. 14163).{67349}

• Artikelnummer: CAY37705-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37705-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe