KU-0058948, CAS 763111-49-5

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone

Purity: ≥95%

Formula Markup: C21H21FN4O2

Formula Weight: 380.4

CAS Number: 763111-49-5

Notes: A PARP1 and PARP2 inhibitor (IC50s = 3.4 and 1.5 nM, respectively); selective for PARP1 over PARP3, PARP4, and tankyrase (IC50s = 40, 1,200, and >10,000 nM, respectively); selectively inhibits the survival of embryonic stem cells lacking Brca1 or Brca2 over embryonic stem cells expressing wild-type Brca1 or Brca2; decreases the survival and induces apoptosis in P39 and MUTZ-3 AML cells at 1 µM; potentiates MS-275-induced cytotoxicity in patient-derived AML cells at 5 nM; reduces survival in PTEN-deficient HCT116 cells but not those expressing wild-type PTEN or HCT116+/neo

• Artikelnummer: CAY42098-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42098-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK