Shelf life (days): 365.0
Formulation: A solution in ethanol
Formal Name: 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11E,14Z-eicosatetraenoic acid
Purity: ≥97%
Formula Markup: C30H47N3O9S
Formula Weight: 625.8
CAS Number: 74841-69-3
Notes: 11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils{11135}, but not in human neutrophils or RBL-1 cells.{11184} It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.{2070,11187} In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.{11187}
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