Shelf life (days): 1460.0
Formulation: A solid
Formal Name: cholest-5-ene-25,26,26,26,27,27,27-d7-3ß,7a-diol
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C27H39D7O2
Formula Weight: 409.7
CAS Number: 349553-94-2
Notes: 7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol (Item No. 20098) by GC- or LC-MS. 7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}
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