Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-butanamide
Purity: ≥95%
Formula Markup: C22H43NO3
Formula Weight: 369.6
CAS Number: 74713-58-9
Notes: C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{13011,48234,48235} It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 10 μM.{13011} C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively).{48234} C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis.{48235}
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