Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexanamide
Purity: ≥98%
Formula Markup: C24H47NO3
Formula Weight: 397.63492
CAS Number: 189894-79-9
Notes: C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{38646},{2814} C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM).{38647} It is metabolically inactive and, unlike C6 L-erythro ceramide (Item No. 24388), C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase.{40661} C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in EL4 T cells when used at a concentration of 10 μM.{13011} [Matreya, LLC. Catalog No. 1809]
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