Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide
Purity: ≥98%
Formula Markup: C26H51NO3
Formula Weight: 425.68808
CAS Number: 175892-43-0
Notes: C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{5258} It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide (Item No. 62540).{5258,38647} C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase.{5258} It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.{40652} [Matreya, LLC. Catalog No. 1810]
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