Shelf life (days): 730.0
Formulation: A solution in ethanol
Formal Name: 3,3’,3’’,3’’’-(((1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-tetradecylpropanamide)
Purity: ≥95%
Formula Markup: C78H160N6O5Si2
Formula Weight: 1318.31344
CAS Number: 3006860-57-4
Notes: A siloxane-incorporated ionizable cationic lipidoid; has been used in the generation of LNPs for the delivery of mRNA and sgRNA in vitro and in vivo; LNPs containing Si5-N14 and encapsulating a luciferase mRNA reporter exhibit increased cellular uptake via micropinocytosis and lipid raft-mediated endocytosis pathways and endosomal escape compared with LNPs containing non-siloxane-incorporated lipids in iMVECs; LNPs containing Si5-N14 and encapsulating a luciferase mRNA reporter selectively accumulate in the lungs in mice; Si5-N14 LNPs encapsulating Cas9 mRNA and GFP sgRNA reduce GFP levels in lung MVECs without increasing BALF cytokine levels in a transgenic GFP mouse model
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