Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]-phenol
Purity: ≥98%
Formula Markup: C38H44N2O6
Formula Weight: 624.76584
CAS Number: 524-17-4
Notes: An isoquinoline alkaloid with diverse biological activities; inhibits IL-1ß-induced THP-1 monocyte adhesion to HUVECs at 20 or 40 µM; inhibits IL-1ß-induced increases in ICAM-1, VCAM-1, and E-selectin levels and activation of NF-?B in HUVECs at 40 µM; inhibits IKs and IKr currents in whole-cell patch-clamp assays using isolated guinea pig ventricular myocytes (IC50s = 16 and 33 µM, respectively); inhibits Kir currents in the same cells at 20 µM; inhibits copper-induced paralysis and decreases in survival in C. elegans at 6.4 µM; increases survival in a mouse model of LPS-induced acute lung injury at 20 mg/kg
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