Product Description: Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification[1][2][3][4].
Applications: Cancer-programmed cell death
Formula: C17H20O5
References: [1]Liu YN, et al. Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock. 2010 Jan;33(1):70-5./[2]Ho CK, et al. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Cancer Invest. 2003;21(5):729-36. /[3]Zhang T, et al. Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. J Adv Res. 2024 Mar 2:S2090-1232(24)00082-1./[4]Chen TH, et al. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008 Jul 1;14(13):4250-8.
CAS Number: 108853-14-1
Molecular Weight: 304.34
Compound Purity: 99.88
Research Area: Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Apoptosis;COX;HIF/HIF Prolyl-Hydroxylase;JNK;NF-κB;Wnt;β-catenin
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