Product Description: Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].
Applications: Cancer-Kinase/protease
Formula: C51H82O21
References: [1]Yan T, et al. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907./[2]Li Y, et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54.
CAS Number: 68124-04-9
Molecular Weight: 1031.18
Compound Purity: 99.96
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL
Target: Akt;Apoptosis;Autophagy;Bcl-2 Family;Caspase;p38 MAPK;PARP;P-glycoprotein
Deutsch
English
