TrkB Agonist Prodrug R13, CAS 1609067-49-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 7,8-bis[[(methylamino)carbonyl]oxy]-2-phenyl-4H-1-benzopyran-4-one

Purity: ≥95%

Formula Markup: C19H16N2O6

Formula Weight: 368.3

CAS Number: 1609067-49-3

Notes: A prodrug form of 7,8-dihydroxyflavone; increases hippocampal phosphorylated levels of TrkB, ERK, and Akt in 5XFAD mice at 43.6 mg/kg per day, p.o.; decreases the number of malformed neurons and increases the number of neurons and active synapses in the hippocampus in 5XFAD mice; decreases the number of plaques and levels of Aβ40 in the hippocampus and frontal cortex and escape latency in the Morris water maze in 5XFAD mice; reduces the levels and activity of δ-secretase and the levels of Il-6, Tnf-α, and Il-1β in brain homogenates from 5XFAD mice

• Artikelnummer: CAY42074-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42074-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK